The TPCSTL was formed in early 1970s by immigrants from Taiwan as a fellowship which met in temporary locations. It joined the Giddings-Lovejoy Presbytery, PCUSA in 1988 and moved into its new church home at 542 Ries Road in Ballwin in 1991.
聖路易臺灣基督長老教會是在一九七O年代初期，由一群來自台灣的移民所設立。教會成立之後並沒有固定的聚會場所。教會於一九八八年加入了美國基督長老會Giddings-Lovejoy中會。靠著神豐富的供應，教會在一九九一年，於新的禮拜堂即教會現址聚會至今。
